Don't Use Creatinine Clearance to Renally Dose All Meds

December 2017

The debate continues about whether to use creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) for renal dosing.

We used to just use the Cockcroft-Gault equation to calculate CrCl for renal dosing. But there's an increase in using eGFR calculated by the Modification of Diet in Renal Disease (MDRD) equation...such as in dosing recommendations for canagliflozin (Invokana) and sacubitril/valsartan (Entresto).

Keep in mind that CrCl and eGFR are NOT interchangeable.

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