Emphasize an Effective Bowel Regimen for Opioid-Induced Constipation

December 2017

Naldemedine (Symproic, sim-PROH-ik) will be another option to treat adults with opioid-induced constipation.

It's a once-daily oral opioid antagonist similar to naloxegol (Movantik) or oral methylnaltrexone (Relistor). They all block opioid binding in the gut to increase GI motility...without affecting analgesia.

Lubiprostone (Amitiza) is another option for opioid-induced constipation. It increases fluid in the gut to stimulate GI motility.

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