Consider a Fixed Dose of Rasburicase for Tumor Lysis Syndrome

December 2017

We're getting questions about rasburicase (Elitek) and other treatments for tumor lysis syndrome (TLS)...a common oncological emergency.

When dying cancer cells spill their contents, it can cause high levels of potassium, phosphorus, and uric acid...plus low calcium.

Consider patients to have active TLS when at least two of these lab abnormalities are present just before or after cancer treatment.

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Table of Contents

New Drugs Save Meropenem/Vaborbactam for Carbapenem-Resistant Enterobacteriaceae
Dosing Don't Use Creatinine Clearance to Renally Dose All Meds
Hematology Oncology Consider a Fixed Dose of Rasburicase for Tumor Lysis Syndrome
Cardiology Look for Post-MI Patients Who May Benefit From an Aldosterone Antagonist
New Drugs Watch for Confusion Between Fiasp and NovoLog
Gastroenterology Know How to Manage Antithrombotics Around Emergent Colonoscopies
New Drugs Emphasize an Effective Bowel Regimen for Opioid-Induced Constipation
COPD Ensure Patients With Mild COPD Are on the Most Cost-Effective Regimen
New Drugs Consider Endari for Patients on Hydroxyurea Who Still Have Sickle Cell Crises
Infectious Diseases Check if Your Hospital Uses Rapid Diagnostic Tests for Acute Infectious Diarrhea
Vaccines Help Patients Understand Differences Between Zostavax and Shingrix