Wait 36 Hours After Stopping an ACEI Before Starting Entresto
You'll hear lots of buzz about Entresto (en-TRESS-toh), a new drug for systolic heart failure.
It's the first "angiotensin receptor neprilysin inhibitor" (ARNI)...and combines valsartan with sacubitril (sah-KYOO-bih-tril).
Sacubitril works by inhibiting the enzyme neprilysin. This increases sodium loss and vasodilation...and enhances ARB efficacy.