Watch for Hypoglycemia in Patients Taking Repaglinide Plus Clopidogrel

October 2015

You'll hear about a potentially dangerous interaction between clopidogrel (Plavix, etc) and repaglinide (Prandin, etc).

We usually think of clopidogrel as a CYP2C19 substrate. But clopidogrel also INHIBITS CYP2C8...causing repaglinide levels to increase.

In fact, clopidogrel can raise repaglinide levels by over 5-fold... and may lead to significant hypoglycemia.

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Table of Contents

Infectious Diseases Use Steroids to Help Reduce Complications in Severe CAP Patients
Extravasations Select Non-Chemo Extravasation Treatment Based on the Offending Med
Anticoagulants Use a Checklist to Help Patients Safely Take DOACs
Biosimilars Check Insurance Coverage at Discharge for Biologics and Biosimilars
New Drugs Watch Out for Severe Hypotension with Flibanserin (Addyi)
Diabetes Lookout for Severe Joint Pain with Gliptins
Substance Use Disorder Look Out for OTC and Rx Meds That Can Be Abused
HIV & AIDS Double Check for Drug Interactions with HIV Therapy
Oral Health Discourage Prophylactic Antibiotics Before Dental Work in Hip/Knee Replacements
Vaccines Add Meningitis B Vaccine to Your Hospital's Asplenia Vaccine Protocol
Interactions Watch for Hypoglycemia in Patients Taking Repaglinide Plus Clopidogrel
Dosing Don't Cap the Dose of Most Chemo Meds in Obese Patients