Lookout for Severe Joint Pain with Gliptins

October 2015

A new FDA warning will spur questions about whether gliptins (sitagliptin, saxagliptin, etc) cause severe joint pain.

This risk seems to be a class effect of gliptins, and it's very rare...but the pain can be disabling and lead to hospitalization.

We know these diabetes meds inhibit dipeptidyl peptidase-4 (DPP-4)...an enzyme that breaks down incretin hormones.

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Table of Contents

Infectious Diseases Use Steroids to Help Reduce Complications in Severe CAP Patients
Extravasations Select Non-Chemo Extravasation Treatment Based on the Offending Med
Anticoagulants Use a Checklist to Help Patients Safely Take DOACs
Biosimilars Check Insurance Coverage at Discharge for Biologics and Biosimilars
New Drugs Watch Out for Severe Hypotension with Flibanserin (Addyi)
Diabetes Lookout for Severe Joint Pain with Gliptins
Substance Use Disorder Look Out for OTC and Rx Meds That Can Be Abused
HIV & AIDS Double Check for Drug Interactions with HIV Therapy
Oral Health Discourage Prophylactic Antibiotics Before Dental Work in Hip/Knee Replacements
Vaccines Add Meningitis B Vaccine to Your Hospital's Asplenia Vaccine Protocol
Interactions Watch for Hypoglycemia in Patients Taking Repaglinide Plus Clopidogrel
Dosing Don't Cap the Dose of Most Chemo Meds in Obese Patients