Lookout for Severe Joint Pain with Gliptins

A new FDA warning will spur questions about whether gliptins (sitagliptin, saxagliptin, etc) cause severe joint pain.

This risk seems to be a class effect of gliptins, and it's very rare...but the pain can be disabling and lead to hospitalization.

We know these diabetes meds inhibit dipeptidyl peptidase-4 (DPP-4)...an enzyme that breaks down incretin hormones.

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