COVID-19 Prevention: Vaccines and Post-Exposure Prophylaxis

September 2026

Questions will come up about 2026-2027 COVID-19 vaccines and the first ORAL med for post-exposure prophylaxis, ensitrelvir (Xocova).

Emphasize that COVID-19 vaccines remain the best tool to reduce the risk of severe disease, long COVID-19, hospitalization, and death.

If your hospital stocks COVID-19 vaccines, expect monovalent products again this season...all updated to target the JN.1 lineage XFG variant. Anticipated options include the mRNA vaccines Comirnaty, Spikevax, and mNexspike...and protein-based Nuvaxovid.


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