Sort Out When to Use Cystatin C in Chronic Kidney Disease

December 2025

Latest chronic kidney disease guidelines spotlight cystatin C as another lab to calculate estimated glomerular filtration rate (eGFR).

We know traditional eGFR equations based on serum creatinine (SCr) can be inaccurate, since SCr is affected by muscle mass, diet, and meds inhibiting its secretion (trimethoprim, piperacillin/tazobactam, etc).

Serum cystatin C is a newer lab that avoids these issues. It’s a protein constantly made by most cells...not just muscle.

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