Adjust Meds for Prolonged Intermittent Renal Replacement Therapy

We’re getting questions about how to dose antibiotics for prolonged intermittent renal replacement therapy (PIRRT).

You may also hear it called sustained low-efficiency dialysis (SLED) or daily dialysis (SLEDD)...or extended daily dialysis (EDD).

Think of PIRRT as a hybrid between traditional hemodialysis and continuous renal replacement therapy (CRRT). Fluid and solute are removed slower than traditional dialysis...but faster than CRRT.

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