Don't Be Surprised to See Low-Dose Naltrexone on Home Med Lists

April 2020

You'll see more patients trying low-dose naltrexone for conditions such as autoimmune diseases or chronic pain.

We're used to seeing this opioid antagonist dosed 50 mg PO once-daily or 380 mg IM monthly for opioid or alcohol use disorder.

But at low oral doses of about 0.5 to 4.5 mg/day, naltrexone is thought to have analgesic and anti-inflammatory effects...by upregulating opioid receptors and increasing endorphin production.

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