Expect Cons to Outweigh Pros for the New CAP Antibiotic Lefamulin (Xenleta)

October 2019

Lefamulin (Xenleta, zen-LEH-tah) will be the first oral and IV med in a new class of "pleuromutilin" antibiotics.

It's approved for community-acquired pneumonia (CAP) and can be used alone to cover common bugs...Strep pneumo, H. flu, and Mycoplasma.

Lefamulin is not inferior to moxifloxacin for CAP treatment. And lefamulin costs about $200/day for IV...and $280/day for tabs.

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