Consider a Combo of IV and Inhaled Antibiotics in Some VAP Patients
Questions will come up about adding nebulized antibiotics for gram-negative ventilator-associated pneumonia (VAP).
About one in three patients fail IV antibiotics for VAP...and poor lung penetration of common VAP antibiotics may contribute to this.
Adding inhaled antibiotics may help reach the site of action. But evidence for benefit is weak. Plus inhaled antibiotics may cause adverse effects, such as bronchospasm or hypoxemia.