Consider Fixed Kcentra Dosing in Emergent Situations if an INR Is Unavailable

August 2017

Debate will brew over fixed versus variable dosing of 4-factor prothrombin complex concentrate (Kcentra) for emergent warfarin reversal.

There's interest in fixed dosing to simplify Kcentra ordering and prepping. This may improve turnaround time...and potentially reduce cost.

But some evidence suggests fixed dosing may not reduce INRs as well as variable dosing...when doses are based on weight and INR.

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