Watch for Tramadol Toxicity in Children
New concerns are emerging about respiratory depression in kids taking tramadol...especially after tonsillectomy or adenoidectomy.
Using tramadol off-label in kids has become more popular...since codeine-containing products have fallen out of favor due to toxicity risk.
Patients who are ultrarapid CYP2D6 metabolizers convert too much codeine to morphine and may develop toxic blood levels. On the other hand, poor 2D6 metabolizers may not get adequate pain relief.