Wait to Renally Adjust Antibiotics in Severely Septic Patients

Questions continue to come up about how to initially dose antibiotics in severe sepsis or septic shock.

Use the following as a guide for individualizing therapy.

What is the optimal time to start antibiotics? Exact timing is debated...but keep aiming for early antibiotic administration. Be aware that Joint Commission's severe sepsis quality measure started October 1...and includes starting antibiotics within 3 hours of presentation.

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