Don’t Jump to IV Tromethamine Despite Increasing Supply

September 2025

Recent FDA approval of a generic for tromethamine injection (Tham) will reignite questions about this old med.

Tromethamine has been around since the 1960s to treat metabolic acidosis...similar to how we use IV sodium bicarbonate.

It binds to acidic protons in the blood to normalize pH...and acts as an osmotic diuretic to urinate out acids.

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