Deflate Hype About Dextromethorphan/Bupropion for Depression

December 2022

You’ll hear buzz about a new extended-release combo of dextromethorphan 45 mg and bupropion 105 mg (Auvelity) for depression.

You might expect bupropion to be the primary active ingredient.

But the manufacturer is actually touting dextromethorphan for its antidepressant effects...as an NMDA receptor blocker.

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