Update Your Colistin and Polymyxin B Protocols
You'll see more focus on optimizing polymyxin antibiotics...due to new guidelines from the Infectious Diseases Society of America and others.
IV colistin (polymyxin E) and polymyxin B have been around for decades. But nephrotoxicity concerns limit their use.
Now we're reaching for polymyxins more often due to increases in multidrug-resistant (MDR) gram-negative organisms, such as carbapenem-resistant Enterobacteriaceae or some Pseudomonas or Acinetobacter.