Be Cautious Reducing DOAC Doses Per Package Labeling

You'll see drug interaction alerts pop up with direct oral anticoagulants (DOACs) such as dabigatran (Pradaxa).

We know interactions are less common with DOACs than warfarin.

But apixaban (Eliquis) and rivaroxaban (Xarelto) are metabolized by CYP3A4...and absorption of all 4 DOACs is affected by P-glycoprotein.

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