Stop SGLT2 Inhibitors When Patients Present With Acute Renal Insufficiency
August 2016
You'll hear debate over whether SGLT2 inhibitors (Jardiance, etc) harm or help the kidneys in type 2 diabetes patients.
New warnings suggest that canagliflozin (Invokana, etc) and dapagliflozin (Farxiga, etc) can cause acute kidney INJURY. But other evidence suggests the SGLT2 inhibitors, or "flozins," may be PROTECTIVE.
For example, flozins can increase serum creatinine (SCr)...usually within the first month. This is likely due to their diuretic effect...and more common in patients with dehydration, poor renal function, or on an NSAID, diuretic, ACEI, or ARB.
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