Maximize Beta-Blockers Before Starting Ivabradine

June 2015

Ivabradine (Corlanor, CORE-lah-nore) will be the first new drug approved for systolic heart failure in a decade.

It works by inhibiting the I_f or "funny" current in the sinoatrial node. This lowers heart rate...withOUT causing a drop in blood pressure.

Ivabradine prevents 1 in 25 patients from being hospitalized over 2 years...when ADDED to standard therapy including an ACEI or ARB, beta-blocker, and aldosterone antagonist. But it DOESN'T reduce overall mortality.

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Heart Failure Maximize Beta-Blockers Before Starting Ivabradine
Diabetes Double Check Diabetes Regimens for Duplicationsat Discharge
Asthma Verify Patients Don't Go Home on Two Albuterol Inhalers
Infectious Diseases Stick to Beta-Lactam/Macrolide Combo for Inpatient CAP Treatment
Constipation Initiate a Bowel Protocol When Scheduled Opioids Are Started
Interactions Watch for Bradycardia With Sofosbuvir and Amiodarone
Substance Use Disorder Think of Powdered Alcohol When Discussing Interactions
Substance Use Disorder Educate Teens About OTC Toxicities
Hypertension Stick With Oral Beta-Blockers in Most ACS Patients with HTN
Coupons Discounts Be Wary of Long-Term Benefits of Drug Coupons
Stroke Have a Pharmacist Respond to Acute Strokes to Help with tPA

Maximize Beta-Blockers Before Starting Ivabradine

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