Clarify Evolving Data Around Antibiotics for Variceal Bleeds
April 2026
There’s growing debate about whether to use prophylactic antibiotics after variceal hemorrhages in patients with cirrhosis.
We know patients with liver disease and cirrhosis are at increased risk of portal hypertension and esophageal or gastric varices. These varices can burst...and lead to fatal bleeding, peritonitis, etc.
Guidelines advise antibiotic prophylaxis (ceftriaxone, etc) in all cases to decrease infection, rebleeding, and mortality risk. Regimens typically last 5 days...or shorter if bleeding and pressors are stopped.
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