Add Olanzapine/Samidorphan to Pre-Op Checklists
You may see the new med combo olanzapine/samidorphan (Lybalvi) used to treat schizophrenia or bipolar disorder.
Samidorphan is a new opioid antagonist derived from naltrexone.
It's added to try to lessen weight gain from olanzapine...possibly by blocking opioid receptors that regulate appetite. But weight gain differences are minimal.