Guide Med Adjustments in Liver Impairment

You'll be asked about med adjustments in patients with liver impairment...since package inserts often lack clear guidance.

Liver enzymes (ALT, AST) are a marker of liver injury...not function. In fact, ALT and AST may be normal in advanced cirrhosis.

Continue to use elevated liver enzymes to detect drug-induced liver injury...and stop possible culprits (acetaminophen, statins, kava, etc).

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