Watch for Statin Interactions With Dabigatran

February 2017

New concerns will crop up about an interaction with simvastatin or lovastatin and the direct oral anticoagulant (DOAC), Pradaxa (dabigatran).

These combos seem to increase bleeding risk.

Simvastatin or lovastatin might increase dabigatran absorption and drug levels by inhibiting P-glycoprotein...a transporter protein that pumps drugs out of cells and into the gut, urine, or bile for excretion.

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