Monitor Potassium Daily in Patients on TMP/SMX and and ACEI or ARB

You'll hear more about possible harm when TMP/SMX (Bactrim, etc) is combined with meds that increase potassium (ACEIs, spironolactone, etc).

This interaction is more risky than previously thought...and is popping up on more drug interaction software.

Trimethoprim decreases urinary excretion of potassium.

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