COVID-19 Vaccines

Full update January 2023

The charts below provide dosing, storage, adverse effects, efficacy, and other information for COVID-19 vaccines approved or authorized in the US and Canada. The American Society of Health System Pharmacists has resources related to COVID-19 vaccines at https://www.ashp.org/COVID-19/Vaccines?loginreturnUrl=SSOCheckOnly. See end of the chart for links to the fact sheets and product labeling.

COVID-19 Vaccines Available in the UNITED STATES

VACCINE^e	DOSE (Primary Series)	DOSE (Booster)	STORAGE/STABILITY	COMMENTS
BNT162b2 (Pfizer-BioNTech)/ mRNA (Comirnaty)^c PURPLE cap^,17,19 (NOT* for ages <12 years^a) Approved for ages ≥12 years;¹⁹ EUA for ages ≥12 years; third dose for immunocompromised.^f,17 Requires dilution with 1.8 mL NS per vial.^17,19 *Purple cap formulation is being phased out. See Gray cap formulation, below.	Primary vaccination for ≥12 years: two 0.3 mL (30 mcg) IM doses 3 weeks apart.^,17,19 Immunocompromised^f: As above, plus 3^rd dose ≥28 days after the 2^nd dose.¹⁷ CDC: An 8-week interval between the first two doses may increase efficacy, but stick with labeled interval for those who need rapid protection (e.g., age ≥65 years, immunocompromised).²⁵	See age-appropriate bivalent mRNA booster.	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC): one month thawed/undiluted vials (includes transport [up to 12 hours]); 6 hours once diluted (vial or pre-drawn syringe).^10,17,19 Room Temp (up to 25^oC): 2 hours (thawed/undiluted); 6 hours once diluted (vial or pre-drawn syringe).^10,17,19	Efficacy: In adolescents, 43% effective against hospitalization 2 to 22 weeks after second dose (Omicron BA.1-predominant period).³⁶ Also see footnote i. Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸ See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
BNT162b2 (Pfizer-BioNTech)/ mRNA (Comirnaty)^c GRAY cap^13,27 (NOT for ages <12 years^a) Approved for ages ≥12 years;²⁷ EUA for ages ≥12 years; third dose for immunocompromised.^f Do NOT dilute.^13,27	See above.	See above.	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC): 10 weeks (unpunctured vial); 12 hours (pre-drawn syringe).^10,13,27 Room Temp (up to 25^oC): 12 hours (unpunctured vial or pre-drawn syringe).^10,13,27 Discard vials 12 hours after first puncture.^13,27 Vaccine should not be used after 18 months from date of manufacture.¹³	See above.
BNT162b2 for 5 through 11 years of age (Pfizer-BioNTech)/ mRNA ORANGE cap and label with orange border³⁰ EUA Requires dilution with 1.3 mL of NS per vial.³⁰	Primary vaccination for 5 to 11 years: two 0.2 mL (10 mcg) IM doses 3 weeks apart.³⁰ Immunocompromised: as above, plus 3^rd dose ≥28 days after the second dose.³⁰	See age-appropriate bivalent mRNA booster.	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks undiluted; 12 hours once diluted (vial).³⁰ Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours once diluted (vial).³⁰ Stable in pre-drawn syringe for 24 hours, with no more than 12 hours at room temperature (up to 30^oC).¹⁰ Vaccine should not be used after 18 months from date of manufacture.³⁰	Efficacy 68% against hospitalization about one month after the second dose (Omicron BA.1-predominant period).³⁶ Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
BNT162b2 for 6 months through 4 years of age (Pfizer-BioNTech)/ mRNA MAROON cap and label with maroon border³² EUA Requires dilution with 2.2 mL of NS per vial.³²	Primary vaccination for 6 months to through 4 years: three 0.2 mL (3 mcg) IM doses. The initial two doses are given 3 weeks apart, followed by a third dose (USING THE BIVALENT vaccine) ≥8 weeks after the second dose.³²	N/A	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (once diluted).³² Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours (once diluted; vial or pre-drawn syringe).^10,32 Vaccine should not be used after 18 months from date of manufacture.³²	Immune response in this age group is similar to that of people 16 through 25 years of age.³²Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
Pfizer BioNTech Bivalent for 6 months through 4 years of age (Pfizer-BioNTech)/ mRNA MAROON cap and label with maroon border³² EUA Requires dilution with 2.2 mL of NS per vial.³²	Third dose of primary series (6 months through 4 years of age): one 0.2 mL (3 mcg) IM dose ≥8 weeks after the second dose of the primary series.³²	N/A	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (once diluted).³² Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours once diluted.³² Vaccine should not be used after 18 months from date of manufacture.³²	Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals >55 years of age.³²Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
Pfizer BioNTech Bivalent booster for ≥12 years of age (original and Omicron BA.4/BA.5) (Pfizer-BioNTech)/ mRNA EUA Do NOT dilute.³⁸	N/A	Booster (≥12 years of age): one 0.3 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³⁸	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (in-use vial).³⁸ Room Temp (up to 25^oC): 12 hours prior to first puncture; 12 hours (in-use vial).³⁸ Vaccine should not be used after 18 months from date of manufacture.³⁸	Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals >55 years of age.³⁸ Also see footnote i.
Pfizer-BioNTech Bivalent booster for 5 through 11 years of age (original and Omicron BA.4/BA.5) (Pfizer-BioNTech)/ mRNA EUA Requires dilution with 1.3 mL of NS per vial.³⁷	N/A	Booster (5 through 11 years of age): one 0.2 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³⁷	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (once diluted).³⁷ Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours (once diluted).³⁷ Vaccine should not be used after 18 months from date of manufacture.³⁷	Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals >55 years of age.³⁷Also see footnote i.
mRNA-1273 (Moderna)/ mRNA (Spikevax)^g RED cap and label with a light blue border (0.2 mg/mL)²¹ Approved (Spikevax) for primary two-dose series in adults ≥18 years of age.²¹ EUA for primary series for ages 12 to 17 years of age, and a third primary series dose for immunocompromised people ≥12 years of age.²	Primary vaccination for ≥12 years: two 0.5 mL (100 mcg) IM doses one month (4 weeks) apart.^,2,21,25 Immunocompromised: as above plus 3^rd dose ≥1 month (≥4 weeks) after the second dose.^2,25 CDC: An 8-week interval between the first two doses may increase efficacy, but stick with labeled interval for those who need rapid protection (e.g., age ≥65 years, immunocompromised).²⁵	See age-appropriate bivalent booster.	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).^2.21 After 30 days, contact manufacturer for guidance before discarding.⁶In-use vial/pre-drawn syringe: 12 hours.^2,10,21 Room temperature (8^oC to 25^oC): 24 hours total. Discard 12 hours after first puncture.^2,21 Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰	Efficacy: In children 12 through 17 years of age, 93.3% effective in preventing symptomatic infection (pre-Omicron data).²Also see footnote i. Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸ See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis. Delayed-type hypersensitivity reaction (e.g., large, red area near injection site) reported most often about a week after first shot. May be itchy, painful, warm, or swollen, and can also involve fingers, elbow, or palm. Not a contraindication to subsequent vaccination.¹⁵
mRNA-1273 (Moderna)/ mRNA 50 mcg in 0.5 mL DARK blue cap and a label with a PURPLE/TEAL border³⁴ (0.1 mg/mL) EUA for primary series (6 through 11 years).³⁴	Primary vaccination for 6 through 11 years: two 0.5 mL (50 mcg) IM doses one-month apart.³⁴ Immunocompromised: as above plus 3^rd dose ≥1 month after the second.³⁴	See age-appropriate bivalent mRNA booster.	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).³⁴ After 30 days, contact manufacturer for guidance before discarding.⁶In-use vial/pre-drawn syringe: 12 hours.^10,34 Room temperature (8^oC to 25^oC): 24 hours total.³⁴ Discard 12 hours after first puncture.³⁴Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰	Immune response in children 6 through 11 years of age is similar to that of adults 18 to 25 years of age.³⁴Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
mRNA-1273 for 6 months through 5 years of age (Moderna)/ mRNA DARK blue cap and label with a MAGENTA border³³ EUA	Primary vaccination for 6 months through 5 years: two 0.25 mL (25 mcg) IM doses one month apart.³³ Immunocompromised: as above, plus 3^rd dose one month after the second dose.³³	N/A	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).³³ After 30 days, contact manufacturer for guidance before discarding.⁶ In-use vial/pre-drawn syringe: 12 hours.^10,33 Room temperature (8^oC to 25^oC): 24 hours total. Discard 12 hours after first puncture.³³Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰	Efficacy 36.8% (2 through 5 years of age) to 50.6% (6 through 23 months of age) against symptomatic infection (Omicron B.1.1.529-predominant period).³³Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
mRNA-1273 Bivalent Booster (original and Omicron BA.4/BA.5) (Moderna)/ mRNA DARK blue cap and a label with a GRAY border³ EUA	N/A	Booster (6 through 11 years of age): one 0.25 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³ Booster (≥12 years of age): one 0.5 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).³ After 30 days, contact manufacturer for guidance before discarding.⁶ In-use vial: 12 hours.³ Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰ Room temperature (8^oC to 25^oC): 24 hours total. Discard 12 hours after first puncture.³Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰	Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals ≥18 years of age.³Also see footnote i.
mRNA-1273 Bivalent Booster (original and Omicron BA.4/BA.5) (Moderna)/ mRNA Dark pink cap and a label with a YELLOW border.⁴¹ EUA	N/A	Booster (6 months through 5 years of age): 0.2 mL IM dose ≥2 months after completion of a primary series with Moderna COVID-19 vaccine.⁴¹	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).⁴¹ After 30 days, contact manufacturer for guidance before discarding.⁶ In-use vial: 8 hours.⁴¹ Room temperature (8^oC to 25^oC): 24 hours total. Discard 8 hours after first puncture.⁴¹	Approval based comparison of immunogenicity data with patients 18 to 25 years of age.⁴¹Also see footnote i.
Ad26.COV2.S Janssen (J&J)/ Viral vector (non-replicating) EUA for adults for whom other vaccines are not available or appropriate, or if they refuse other vaccines.⁹	Primary vaccination for ≥18 years: one 0.5 mL IM dose.⁹ Immunocompromised: as above, plus 2^nd dose, (mRNA vaccine) ≥28 days later.²⁵	Booster: one 0.5 mL IM dose ≥2 months after primary vaccination (mRNA booster preferred).^9,25	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): Up to 11 months, not to exceed manufacturer expiration date (unpunctured vial).³¹ In-use vial: 6 hours.⁹ Pre-drawn syringe: 6 hours after first puncture of source vial.^9,10 Room temperature (9^oC to 25^oC): unpunctured vial: 12 hours.⁹ In-use vial: 2 hours.⁹ Pre-drawn syringe: 2 hours after first puncture of source vial.¹⁰	Efficacy 45.3% against symptomatic infection two to four months after mRNA booster (Omicron BA.1-predominant period).⁷Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about thrombosis with thrombocytopenia syndrome (TTS) and other rare side effects of viral vector COVID-19 vaccines.
NVX-CoV2373 (Novavax)/ Recombinant protein subunit, adjuvanted EUA	Primary vaccination for ≥12 years of age: two 0.5 mL IM doses three weeks apart.¹⁴ Immunocompromised: response may be diminished.¹⁴	Booster (≥18 years of age): one 0.5 mL IM dose ≥6 months after primary vaccination with any COVID-19 vaccine, for patients unable or unwilling to receive the bivalent mRNA booster.¹⁴	Refrigerator (2^oC to 8^oC): 6 hours (in-use vial or pre-drawn syringe).^10,14 Room temperature (≤25^oC): 6 hours (in-use vial or pre-drawn syringe).^10,14	Efficacy: See footnote i.

VACCINE^e

DOSE

(Primary Series)

DOSE (Booster)

STORAGE/STABILITY

COMMENTS

BNT162b2

(Pfizer-BioNTech)/

mRNA

(Comirnaty)^c

PURPLE cap*^,17,19

(NOT for ages

<12 years^a)

Approved for ages ≥12 years;¹⁹ EUA for ages ≥12 years; third dose for immunocompromised.^f,17

Requires dilution with

1.8 mL NS per vial.^17,19

*Purple cap formulation is being phased out. See Gray cap formulation, below.

Primary vaccination for ≥12 years: two 0.3 mL (30 mcg) IM doses 3 weeks apart.**^,17,19

Immunocompromised^f: As above, plus 3^rd dose

≥28 days after the 2^nd dose.¹⁷

**CDC: An 8-week interval between the first two doses may increase efficacy, but stick with labeled interval for those who need rapid protection (e.g., age ≥65 years, immunocompromised).²⁵

See age-appropriate bivalent mRNA booster.

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC): one month thawed/undiluted vials (includes transport [up to 12 hours]); 6 hours once diluted (vial or pre-drawn syringe).^10,17,19

Room Temp (up to 25^oC): 2 hours (thawed/undiluted); 6 hours once diluted (vial or pre-drawn syringe).^10,17,19

Efficacy: In adolescents, 43% effective against hospitalization 2 to 22 weeks after second dose (Omicron BA.1-predominant period).³⁶ Also see footnote i.
Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

BNT162b2

(Pfizer-BioNTech)/

mRNA

(Comirnaty)^c

GRAY cap^13,27

(NOT for ages

<12 years^a)

Approved for ages ≥12 years;²⁷ EUA for ages ≥12 years; third dose for immunocompromised.^f

Do NOT dilute.^13,27

See above.

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC):

10 weeks (unpunctured vial); 12 hours (pre-drawn syringe).^10,13,27

Room Temp (up to 25^oC): 12 hours (unpunctured vial or pre-drawn syringe).^10,13,27

Discard vials 12 hours after first puncture.^13,27

Vaccine should not be used after 18 months from date of manufacture.¹³

See above.

BNT162b2 for 5 through 11 years of age

(Pfizer-BioNTech)/

mRNA

ORANGE cap and label with orange border³⁰

EUA

Requires dilution with

1.3 mL of NS per vial.³⁰

Primary vaccination for 5 to 11 years: two

0.2 mL (10 mcg) IM doses 3 weeks apart.³⁰

Immunocompromised: as above, plus 3^rd dose ≥28 days after the second dose.³⁰

See age-appropriate bivalent mRNA booster.

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks undiluted; 12 hours once diluted (vial).³⁰

Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours once diluted (vial).³⁰

Stable in pre-drawn syringe for 24 hours, with no more than 12 hours at room temperature (up to 30^oC).¹⁰

Vaccine should not be used after 18 months from date of manufacture.³⁰

Efficacy 68% against hospitalization about one month after the second dose (Omicron BA.1-predominant period).³⁶ Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

BNT162b2 for 6 months through 4 years of age

(Pfizer-BioNTech)/

mRNA

MAROON cap and label with maroon border³²

EUA

Requires dilution with

2.2 mL of NS per vial.³²

Primary vaccination for 6 months to through 4 years: three 0.2 mL (3 mcg) IM doses. The initial two doses are given 3 weeks apart, followed by a third dose (USING THE BIVALENT vaccine) ≥8 weeks after the second dose.³²

N/A

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (once diluted).³²

Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours (once diluted; vial or pre-drawn syringe).^10,32

Vaccine should not be used after 18 months from date of manufacture.³²

Immune response in this age group is similar to that of people 16 through 25 years of age.³²Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

Pfizer BioNTech Bivalent for 6 months through 4 years of age

(Pfizer-BioNTech)/

mRNA

MAROON cap and label with maroon border³²

EUA

Requires dilution with

2.2 mL of NS per vial.³²

Third dose of primary series (6 months through 4 years of age): one 0.2 mL (3 mcg) IM dose ≥8 weeks after the second dose of the primary series.³²

N/A

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (once diluted).³²

Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours once diluted.³²

Vaccine should not be used after 18 months from date of manufacture.³²

Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals >55 years of age.³²Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

Pfizer BioNTech Bivalent booster for ≥12 years of age (original and Omicron BA.4/BA.5)

(Pfizer-BioNTech)/

mRNA

EUA

Do NOT dilute.³⁸

N/A

Booster (≥12 years of age): one 0.3 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³⁸

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (in-use vial).³⁸

Room Temp (up to 25^oC): 12 hours prior to first puncture; 12 hours (in-use vial).³⁸

Vaccine should not be used after 18 months from date of manufacture.³⁸

Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals >55 years of age.³⁸ Also see footnote i.

Pfizer-BioNTech Bivalent booster for 5 through 11 years of age (original and Omicron BA.4/BA.5)

(Pfizer-BioNTech)/

mRNA

EUA

Requires dilution with

1.3 mL of NS per vial.³⁷

N/A

Booster (5 through 11 years of age): one 0.2 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³⁷

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks (undiluted); 12 hours (once diluted).³⁷

Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours (once diluted).³⁷

Vaccine should not be used after 18 months from date of manufacture.³⁷

Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals >55 years of age.³⁷Also see footnote i.

mRNA-1273

(Moderna)/

mRNA

(Spikevax)^g

RED cap and label with a light blue border
(0.2 mg/mL)²¹

Approved (Spikevax) for primary two-dose series in adults ≥18 years of age.²¹

EUA for primary series for ages 12 to 17 years of age, and a third primary series dose for immunocompromised people ≥12 years of age.²

Primary vaccination for ≥12 years: two 0.5 mL (100 mcg) IM doses one month (4 weeks) apart.*^,2,21,25

Immunocompromised: as above plus 3^rd dose ≥1 month (≥4 weeks) after the second dose.^2,25

*CDC: An 8-week interval between the first two doses may increase efficacy, but stick with labeled interval for those who need rapid protection (e.g., age ≥65 years, immunocompromised).²⁵

See age-appropriate bivalent booster.

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).^2.21 After 30 days, contact manufacturer for guidance before discarding.⁶In-use vial/pre-drawn syringe: 12 hours.^2,10,21

Room temperature (8^oC to 25^oC): 24 hours total. Discard 12 hours after first puncture.^2,21 Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰

Efficacy: In children 12 through 17 years of age, 93.3% effective in preventing symptomatic infection (pre-Omicron data).²Also see footnote i.
Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
Delayed-type hypersensitivity reaction (e.g., large, red area near injection site) reported most often about a week after first shot. May be itchy, painful, warm, or swollen, and can also involve fingers, elbow, or palm. Not a contraindication to subsequent vaccination.¹⁵

mRNA-1273

(Moderna)/

mRNA

50 mcg in 0.5 mL

DARK blue cap and a label with a PURPLE/TEAL border³⁴

(0.1 mg/mL)

EUA for primary series (6 through 11 years).³⁴

Primary vaccination for 6 through 11 years: two 0.5 mL (50 mcg) IM doses one-month apart.³⁴

Immunocompromised: as above plus 3^rd dose ≥1 month after the second.³⁴

See age-appropriate bivalent mRNA booster.

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).³⁴ After 30 days, contact manufacturer for guidance before discarding.⁶In-use vial/pre-drawn syringe: 12 hours.^10,34

Room temperature (8^oC to 25^oC): 24 hours total.³⁴ Discard 12 hours after first puncture.³⁴Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰

Immune response in children 6 through 11 years of age is similar to that of adults 18 to 25 years of age.³⁴Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

mRNA-1273 for 6 months through 5 years of age

(Moderna)/

mRNA

DARK blue cap and label with a MAGENTA border³³

EUA

Primary vaccination for 6 months through 5 years: two 0.25 mL (25 mcg) IM doses one month apart.³³

Immunocompromised: as above, plus 3^rd dose one month after the second dose.³³

N/A

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC):

30 days after thawing (prior to first use).³³ After 30 days, contact manufacturer for guidance before discarding.⁶ In-use vial/pre-drawn syringe: 12 hours.^10,33

Room temperature (8^oC to 25^oC): 24 hours total. Discard 12 hours after first puncture.³³Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰

Efficacy 36.8% (2 through 5 years of age) to 50.6% (6 through 23 months of age) against symptomatic infection (Omicron B.1.1.529-predominant period).³³Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

mRNA-1273 Bivalent Booster (original and Omicron BA.4/BA.5)

(Moderna)/

mRNA

DARK blue cap and a label with a GRAY border³

EUA

N/A

Booster (6 through 11 years of age): one 0.25 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³

Booster (≥12 years of age): one 0.5 mL IM dose ≥2 months after completion of primary series of any COVID-19 vaccine or booster.³

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).³ After 30 days, contact manufacturer for guidance before discarding.⁶ In-use vial: 12 hours.³ Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰

Room temperature

(8^oC to 25^oC): 24 hours total. Discard 12 hours after first puncture.³Pre-drawn syringe: 12 hours after first puncture of source vial.¹⁰

Approval based on immunogenicity data from a different bivalent booster (original and Omicron BA.1) in individuals ≥18 years of age.³Also see footnote i.

mRNA-1273 Bivalent Booster (original and Omicron BA.4/BA.5)

(Moderna)/

mRNA

Dark pink cap and a label with a YELLOW border.⁴¹

EUA

N/A

Booster

(6 months through 5 years of age): 0.2 mL IM dose ≥2 months after completion of a primary series with Moderna COVID-19 vaccine.⁴¹

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).⁴¹ After 30 days, contact manufacturer for guidance before discarding.⁶ In-use vial: 8 hours.⁴¹

Room temperature

(8^oC to 25^oC): 24 hours total. Discard 8 hours after first puncture.⁴¹

Approval based comparison of immunogenicity data with patients 18 to 25 years of age.⁴¹Also see footnote i.

Ad26.COV2.S

Janssen (J&J)/

Viral vector (non-replicating)

EUA for adults for whom other vaccines are not available or appropriate, or if they refuse other vaccines.⁹

Primary vaccination for ≥18 years: one 0.5 mL IM dose.⁹

Immunocompromised: as above, plus 2^nd dose, (mRNA vaccine) ≥28 days later.²⁵

Booster: one
0.5 mL IM dose ≥2 months after primary vaccination (mRNA booster preferred).^9,25

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): Up to 11 months, not to exceed manufacturer expiration date (unpunctured vial).³¹

In-use vial: 6 hours.⁹ Pre-drawn syringe: 6 hours after first puncture of source vial.^9,10

Room temperature (9^oC to 25^oC):

unpunctured vial: 12 hours.⁹ In-use vial: 2 hours.⁹ Pre-drawn syringe: 2 hours after first puncture of source vial.¹⁰

Efficacy 45.3% against symptomatic infection two to four months after mRNA booster (Omicron BA.1-predominant period).⁷Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about thrombosis with thrombocytopenia syndrome (TTS) and other rare side effects of viral vector COVID-19 vaccines.

NVX-CoV2373

(Novavax)/

Recombinant protein subunit, adjuvanted

EUA

Primary vaccination for ≥12 years of age: two 0.5 mL IM doses three weeks apart.¹⁴

Immunocompromised: response may be diminished.¹⁴

Booster (≥18 years of age): one 0.5 mL IM dose ≥6 months after primary vaccination with any COVID-19 vaccine, for patients unable or unwilling to receive the bivalent mRNA booster.¹⁴

Refrigerator (2^oC to 8^oC): 6 hours (in-use vial or pre-drawn syringe).^10,14

Room temperature (≤25^oC): 6 hours (in-use vial or pre-drawn syringe).^10,14

Efficacy: See footnote i.

--Continue to the next page for the COVID-19 Vaccines Available in Canada chart.--

COVID-19 Vaccines Available in CANADA

VACCINE^e	DOSE (Primary Series)	DOSE (Booster)	STORAGE/STABILITY	COMMENTS
BNT162b2 (Pfizer-BioNTech)/ mRNA (Comirnaty) PURPLE cap¹⁸ (NOT for ages <12 years^a) Requires dilution with 1.8 mL NS per vial.¹⁸	Primary vaccination for ≥12 years: two 0.3 mL (30 mcg) IM doses 3 weeks apart (8-week interval preferred).^18,20 Immunocompromised^f: As above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.^18,20	Bivalent booster preferred.^20,h Booster (≥12 years [approved for ≥16 years]):^h one 0.3 mL (30 mcg) IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,18 Immunocompromised^f,h: as above.²⁰	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC): 1 month thawed/undiluted vials (includes transport [up to 12 hours]); 6 hours once diluted (vial or pre-drawn syringe).^10,18 Room Temp (up to 25^oC): 2 hours (thawed/undiluted); 6 hours (once diluted [vial or pre-drawn syringe]).^10,18	Efficacy: In adolescents, 43% effective against hospitalization 2 to 22 weeks after second dose (Omicron BA.1-predominant period).³⁶Also see footnote i. Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸ See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
BNT162b2 (Pfizer-BioNTech)/ mRNA (Comirnaty) GRAY cap¹⁸ (NOT for ages <12 years^a) Do NOT dilute.¹⁸	See above.	See above.	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC): 10 weeks (unpunctured vial).¹⁸ 12 hours (pre-drawn syringe).¹⁰ Room Temp (up to 25^oC): 12 hours (unpunctured vial or pre-drawn syringe).^10,18Discard vials 12 hours after first puncture.¹⁸ Vaccine should not be used after 12 months from date of manufacture.¹⁸	See above.
BNT162b2 for 5 through 11 years of age (Pfizer-BioNTech)/ mRNA (Comirnaty) ORANGE cap and label with orange border¹⁸ Requires dilution with 1.3 mL of NS per vial.¹⁸	Primary vaccination for 5 to 11 years: two 0.2 mL (10 mcg) IM doses 21 days apart. (≥8-week interval preferred).^18,20 Immunocompromised: as above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.^18,20	First Booster: one 0.2 mL (10 mcg) IM dose ≥6 months after last primary dose.¹⁸	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks undiluted; 12 hours once diluted (vial).¹⁸ Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours (once diluted [vial]).¹⁸ Stable in pre-drawn syringe for 24 hours, with no more than 12 hours at room temperature (up to 30^oC).¹⁰ Vaccine should not be used after 12 months from date of manufacture.¹⁸	Efficacy 68% against hospitalization about one month after the second dose (Omicron BA.1-predominant period).³⁶ Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
Pfizer-BioNTech Bivalent booster (original and Omicron BA.1) (original and Omicron BA.4/BA.5) for ≥12 years of age (Pfizer-BioNTech)/ mRNA (Comirnaty) Do NOT dilute.^39,40	N/A	Booster (≥12 years of age): one 0.3 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,39,40	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC): 10 weeks (unpunctured vial).^39,40 Room Temp (up to 25^oC): 12 hours (unpunctured vial).^39,40 Discard vials 12 hours after first puncture.^39,40 Vaccine should not be used after 12 months from date of manufacture.³⁹	Approval based on immunogenicity data in individuals >55 years of age.^39,40Also see footnote i.
Pfizer-BioNTech Bivalent booster (original and Omicron BA.4/BA.5) for 5 through 11 years of age (Pfizer-BioNTech)/ mRNA (Comirnaty) Orange cap⁴⁰ Requires dilution with 1.3 mL of NS per vial.⁴⁰	N/A	Booster (5 through 11 years of age): one 0.2 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,40	Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d. Refrigerator (2^oC to 8^oC): 10 weeks (undiluted). 12 hours once diluted.⁴⁰ Room Temp (up to 25^oC): 12 hours (undiluted). 12 hours once diluted.⁴⁰ Vaccine should not be used after 12 months from date of manufacture.⁴⁰	Approval based on immunogenicity data of the bivalent original/Omicron BA.1 booster in individuals >55 years of age.⁴⁰Also see footnote i.
mRNA-1273 (Moderna)/ mRNA (Spikevax) RED cap and label with a light blue border (0.2 mg/mL)²²	Primary vaccination for ≥12 years: two 0.5 mL (100 mcg) IM doses 1 month (4 weeks) apart (8-week interval preferred).^20,22 6 to 11 years: two 0.25 mL (50 mcg) IM doses 4 weeks apart (≥8-week interval preferred).^20,22 Immunocompromised^f: as above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.²⁰	If age ≥18 years, bivalent booster preferred.^11,h Booster (≥12 years^b): one 0.25 mL (50 mcg) IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,22 Immunocompromised^f: as above, but 100 mcg (0.5 mL) instead of 50 mcg (0.25 mL) can be used for first or second booster if ≥18 years.²⁰	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).²² In-use vial: 24 hours.²²Pre-drawn syringe: 12 hours from first puncture of source vial.¹⁰ Room temperature (8^oC to 25^oC): unpunctured or in-use vial: 24 hours total.^12,22 Pre-drawn syringe: 12 hours from first puncture of source vial.¹⁰	Efficacy: In children 12 through 17 years of age, 93.3% effective in preventing symptomatic infection (pre-Omicron data).²Also see footnote i. Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸ See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis. Delayed-type hypersensitivity reaction (e.g., large, red area near injection site) reported most often about a week after first shot. May be itchy, painful, warm, or swollen, and can also involve fingers, elbow, or palm. Not a contraindication to subsequent vaccination.¹⁵
mRNA-1273 (Moderna)/ mRNA (Spikevax) ROYAL blue cap and a label with a PURPLE border²² (0.1 mg/mL) Approved for primary series (6 months through 11 years) and 50 mcg booster (adults)²²	Primary vaccination for 6 months through 5 years: two 0.25 mL (25 mcg) IM doses 4 weeks apart (≥8 weeks preferred).^22,35 Primary vaccination for 6 through 11 years: two 0.5 mL (50 mcg) IM doses 4 weeks apart (≥8 weeks preferred).^20,22 Immunocompromised: as above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.^20,35	Bivalent booster preferred if ≥18 years of age.^11,h Booster (≥18 years): one 0.5 mL (50 mcg) IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,20	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).²² In-use vial: 24 hours.²² Room temperature (8^oC to 25^oC): in-use vial: 24 hours.²²	Efficacy 36.8% (2 through 5 years of age) to 50.6% (6 through 23 months of age) against symptomatic infection (Omicron B.1.1.529-predominant period).³³Also see footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
mRNA-1273 Bivalent Booster (original and Omicron BA.1) (original and Omicron BA.4/BA.5) (Moderna)/ mRNA (Spikevax Bivalent)	N/A	Booster (≥18 years of age): one 0.5 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the last COVID-19 vaccine dose or infection.^1,11.42	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).^1,42 In-use vial: 24 hours.^1,42 Room temperature (8^oC to 25^oC): 24 hours total, in-use or unpunctured.^1,42	Approval based on immunogenicity data.¹Also see footnote i.
Ad26.COV2.S Janssen (J&J)/ Viral vector (non-replicating) (Jcovden) mRNA vaccine preferred.²⁰	Primary vaccination for ≥18 years: one 0.5 mL IM dose.²⁴ Immunocompromised: as above, plus 2^nd dose, (mRNA vaccine) ≥28 days later.²⁰	Bivalent booster preferred.^11,h First Booster (only when all other vaccines are contraindicated): ≥2 months after the first dose.^11,24	Shipping/long-term storage (freezer): See footnote d. Refrigerator (2^oC to 8^oC): up to 11 months, not to exceed manufacturer expiration date (unpunctured vial).²⁴ In-use vial/pre-drawn syringe: 6 hours.^10,24 Room temperature (9^oC to 25^oC): unpunctured vial: 12 hours.²⁴ In-use vial: 3 hours.²⁴Pre-drawn syringe: 2 hours.¹⁰	Efficacy: See footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about thrombosis with thrombocytopenia syndrome (TTS) and other rare side effects of viral vector COVID-19 vaccines.
ChAdOx1-S (AstraZeneca)/Viral vector (non-replicating) (Vaxzevria) mRNA vaccine preferred.²⁰	Primary vaccination for ≥18 years of age: two 0.5 mL IM doses 4 to 12 weeks apart (≥8-week interval preferred).^16,20 Immunocompromised: As above plus 3^rd dose (mRNA vaccine) ≥28 days later.²⁰	N/A	Refrigerator (2^oC to 8^oC): manufacturer expiration date (unpunctured vial); 48 hours (in-use vial).¹⁶ Room temperature (≤30^oC): 6 hours (in-use vial). Vial can be re-refrigerated, but the cumulative storage at room temperature cannot exceed 6 hours, and the total cumulative storage time cannot exceed 48 hours.¹⁶	Efficacy: See footnote i. See our FAQ, Communicating About COVID-19 Vaccination, for information about thrombosis with thrombocytopenia syndrome (TTS) and other rare side effects of viral vector COVID-19 vaccines.
NVX-CoV2373 (Novavax)/ Recombinant protein subunit, adjuvanted (Nuvaxovid) mRNA vaccine preferred.²⁰	Primary vaccination for ≥12 years of age: two 0.5 mL IM doses three weeks apart (8-week interval preferred).^8,20 Immunocompromised^f: As above, plus 3rd dose, with 4 to 8 weeks between each of the three doses (mRNA vaccine preferred).²⁰	Bivalent booster preferred.^11,h Booster (≥18 years of age): one 0.5 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the last COVID-19 vaccine dose or infection.^8,11	Refrigerator (2^oC to 8^oC): 6 hours (in-use vial or pre-drawn syringe).^8,10 Room temperature (≤25^oC): 6 hours (in-use vial or pre-drawn syringe).^8,10	Effectiveness estimates unknown for current variants.²⁰ Also see footnote i.
*Covifenz* (Medicago)/ Recombinant spike protein in plant-based virus-like particles, adjuvanted mRNA vaccine preferred.²⁰	Primary vaccination for 18 to 64 years of age: two 0.5 mL IM doses 21 days apart (8-week interval preferred).^20,26 Immunocompromised^f: As above, plus 3rd dose, with 4 to 8 weeks between each of the three doses (mRNA vaccine preferred).²⁰	N/A	Refrigerator (2^oC to 8^oC). Until expiration date on vaccine and adjuvant vials (unpunctured).²⁶ In-use vial (mixed): 20^oC to 30^oC for 6 hours (do not refrigerate once mixed).²⁶	Effectiveness estimates unknown for current variants.²⁰ Also see footnote i. Requires mixing of adjuvant and antigen before use (see product labeling for instructions).²⁶ Produced using the genomic sequence of the spike protein of the original strain.²⁶ May contain trace amounts of kanamycin or carbenicillin.²⁶

VACCINE^e

DOSE (Primary Series)

DOSE (Booster)

STORAGE/STABILITY

COMMENTS

BNT162b2

(Pfizer-BioNTech)/

mRNA

(Comirnaty)

PURPLE cap¹⁸

(NOT for ages

<12 years^a)

Requires dilution with

1.8 mL NS per vial.¹⁸

Primary vaccination for ≥12 years: two 0.3 mL (30 mcg) IM doses 3 weeks apart (8-week interval preferred).^18,20

Immunocompromised^f: As above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.^18,20

Bivalent booster preferred.^20,h

Booster (≥12 years [approved for ≥16 years]):^h one 0.3 mL (30 mcg) IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,18

Immunocompromised^f,h: as above.²⁰

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 1 month thawed/undiluted vials (includes transport [up to 12 hours]); 6 hours once diluted (vial or pre-drawn syringe).^10,18

Room Temp (up to 25^oC): 2 hours (thawed/undiluted); 6 hours (once diluted [vial or pre-drawn syringe]).^10,18

Efficacy: In adolescents, 43% effective against hospitalization 2 to 22 weeks after second dose (Omicron BA.1-predominant period).³⁶Also see footnote i.
Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

BNT162b2

(Pfizer-BioNTech)/

mRNA

(Comirnaty)

GRAY cap¹⁸

(NOT for ages

<12 years^a)

Do NOT dilute.¹⁸

See above.

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC):

10 weeks (unpunctured vial).¹⁸ 12 hours (pre-drawn syringe).¹⁰

Room Temp (up to 25^oC): 12 hours (unpunctured vial or pre-drawn syringe).^10,18Discard vials 12 hours after first puncture.¹⁸

Vaccine should not be used after 12 months from date of manufacture.¹⁸

See above.

BNT162b2 for 5 through 11 years of age

(Pfizer-BioNTech)/

mRNA

(Comirnaty)

ORANGE cap and label with orange border¹⁸

Requires dilution with

1.3 mL of NS per vial.¹⁸

Primary vaccination for 5 to 11 years: two 0.2 mL (10 mcg) IM doses 21 days apart. (≥8-week interval preferred).^18,20

Immunocompromised: as above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.^18,20

First Booster: one 0.2 mL (10 mcg) IM dose ≥6 months after last primary dose.¹⁸

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC) (option if vials arrive frozen or refrigerated): 10 weeks undiluted; 12 hours once diluted (vial).¹⁸

Room Temp (up to 25^oC): 12 hours (undiluted); 12 hours (once diluted [vial]).¹⁸

Stable in pre-drawn syringe for 24 hours, with no more than 12 hours at room temperature (up to 30^oC).¹⁰

Vaccine should not be used after 12 months from date of manufacture.¹⁸

Efficacy 68% against hospitalization about one month after the second dose (Omicron BA.1-predominant period).³⁶ Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

Pfizer-BioNTech Bivalent booster (original and Omicron BA.1)

(original and Omicron BA.4/BA.5) for ≥12 years of age

(Pfizer-BioNTech)/

mRNA

(Comirnaty)

Do NOT dilute.^39,40

N/A

Booster (≥12 years of age): one 0.3 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,39,40

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC):

10 weeks (unpunctured vial).^39,40

Room Temp (up to 25^oC): 12 hours (unpunctured vial).^39,40

Discard vials 12 hours after first puncture.^39,40

Vaccine should not be used after 12 months from date of manufacture.³⁹

Approval based on immunogenicity data in individuals >55 years of age.^39,40Also see footnote i.

Pfizer-BioNTech Bivalent booster (original and Omicron BA.4/BA.5) for 5 through 11 years of age

(Pfizer-BioNTech)/

mRNA

(Comirnaty)

Orange cap⁴⁰

Requires dilution with

1.3 mL of NS per vial.⁴⁰

N/A

Booster (5 through 11 years of age): one 0.2 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,40

Shipping/long-term storage (ultra-low temp freezer, freezer): See footnote d.

Refrigerator (2^oC to 8^oC):

10 weeks (undiluted). 12 hours once diluted.⁴⁰

Room Temp (up to 25^oC): 12 hours (undiluted). 12 hours once diluted.⁴⁰

Vaccine should not be used after 12 months from date of manufacture.⁴⁰

Approval based on immunogenicity data of the bivalent original/Omicron BA.1 booster in individuals >55 years of age.⁴⁰Also see footnote i.

mRNA-1273

(Moderna)/

mRNA

(Spikevax)

RED cap and label with a light blue border (0.2 mg/mL)²²

Primary vaccination for ≥12 years: two 0.5 mL (100 mcg) IM doses 1 month (4 weeks) apart (8-week interval preferred).^20,22

6 to 11 years: two 0.25 mL (50 mcg) IM doses 4 weeks apart (≥8-week interval preferred).^20,22

Immunocompromised^f: as above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.²⁰

If age ≥18 years, bivalent booster preferred.^11,h

Booster (≥12 years^b):

one 0.25 mL (50 mcg) IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,22

Immunocompromised^f: as above, but 100 mcg (0.5 mL) instead of 50 mcg (0.25 mL) can be used for first or second booster if ≥18 years.²⁰

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).²²

In-use vial: 24 hours.²²Pre-drawn syringe: 12 hours from first puncture of source vial.¹⁰

Room temperature (8^oC to 25^oC): unpunctured or in-use vial: 24 hours total.^12,22 Pre-drawn syringe: 12 hours from first puncture of source vial.¹⁰

Efficacy: In children 12 through 17 years of age, 93.3% effective in preventing symptomatic infection (pre-Omicron data).²Also see footnote i.
Lymphadenopathy (16%) may interfere with imaging (e.g., mammography) for four to six weeks after vaccination.²⁸
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.
Delayed-type hypersensitivity reaction (e.g., large, red area near injection site) reported most often about a week after first shot. May be itchy, painful, warm, or swollen, and can also involve fingers, elbow, or palm. Not a contraindication to subsequent vaccination.¹⁵

mRNA-1273

(Moderna)/

mRNA

(Spikevax)

ROYAL blue cap and a label with a PURPLE border²²

(0.1 mg/mL)

Approved for primary series (6 months through 11 years) and 50 mcg booster (adults)²²

Primary vaccination for 6 months through 5 years: two 0.25 mL (25 mcg) IM doses 4 weeks apart (≥8 weeks preferred).^22,35

Primary vaccination for 6 through 11 years: two 0.5 mL (50 mcg) IM doses 4 weeks apart (≥8 weeks preferred).^20,22

Immunocompromised: as above plus 3^rd dose, with 4 to 8 weeks between each of the three doses.^20,35

Bivalent booster preferred if ≥18 years of age.^11,h

Booster (≥18 years): one 0.5 mL (50 mcg) IM dose

≥6 months (≥3 months in the event of heightened epidemiologic risk) after the primary series, booster, or infection.^11,20

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): 30 days after thawing (prior to first use).²²

In-use vial: 24 hours.²²

Room temperature (8^oC to 25^oC): in-use vial: 24 hours.²²

Efficacy 36.8% (2 through 5 years of age) to 50.6% (6 through 23 months of age) against symptomatic infection (Omicron B.1.1.529-predominant period).³³Also see footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about myocarditis/pericarditis.

mRNA-1273 Bivalent Booster (original and Omicron BA.1)

(original and Omicron BA.4/BA.5)

(Moderna)/

mRNA

(Spikevax Bivalent)

N/A

Booster (≥18 years of age): one 0.5 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the last COVID-19 vaccine dose or infection.^1,11.42

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC):

30 days after thawing (prior to first use).^1,42 In-use vial: 24 hours.^1,42

Room temperature

(8^oC to 25^oC): 24 hours total, in-use or unpunctured.^1,42

Approval based on immunogenicity data.¹Also see footnote i.

Ad26.COV2.S

Janssen (J&J)/

Viral vector (non-replicating)

(Jcovden)

mRNA vaccine preferred.²⁰

Primary vaccination for ≥18 years: one 0.5 mL IM dose.²⁴

Immunocompromised: as above, plus 2^nd dose, (mRNA vaccine) ≥28 days later.²⁰

Bivalent booster preferred.^11,h

First Booster (only when all other vaccines are contraindicated): ≥2 months after the first dose.^11,24

Shipping/long-term storage (freezer): See footnote d.

Refrigerator (2^oC to 8^oC): up to 11 months, not to exceed manufacturer expiration date (unpunctured vial).²⁴ In-use vial/pre-drawn syringe:

6 hours.^10,24

Room temperature (9^oC to 25^oC): unpunctured vial: 12 hours.²⁴ In-use vial: 3 hours.²⁴Pre-drawn syringe: 2 hours.¹⁰

Efficacy: See footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about thrombosis with thrombocytopenia syndrome (TTS) and other rare side effects of viral vector COVID-19 vaccines.

ChAdOx1-S

(AstraZeneca)/Viral vector (non-replicating) (Vaxzevria)

mRNA vaccine preferred.²⁰

Primary vaccination for ≥18 years of age:

two 0.5 mL IM doses

4 to 12 weeks apart (≥8-week interval preferred).^16,20

Immunocompromised:

As above plus 3^rd dose (mRNA vaccine) ≥28 days later.²⁰

N/A

Refrigerator (2^oC to 8^oC): manufacturer expiration date (unpunctured vial); 48 hours (in-use vial).¹⁶

Room temperature (≤30^oC): 6 hours (in-use vial). Vial can be re-refrigerated, but the cumulative storage at room temperature cannot exceed 6 hours, and the total cumulative storage time cannot exceed

48 hours.¹⁶

Efficacy: See footnote i.
See our FAQ, Communicating About COVID-19 Vaccination, for information about thrombosis with thrombocytopenia syndrome (TTS) and other rare side effects of viral vector COVID-19 vaccines.

NVX-CoV2373

(Novavax)/

Recombinant protein subunit, adjuvanted

(Nuvaxovid)

mRNA vaccine preferred.²⁰

Primary vaccination for ≥12 years of age: two 0.5 mL IM doses three weeks apart (8-week interval preferred).^8,20

Immunocompromised^f: As above, plus 3rd dose, with 4 to 8 weeks between each of the three doses (mRNA vaccine preferred).²⁰

Bivalent booster preferred.^11,h

Booster (≥18 years of age): one 0.5 mL IM dose ≥6 months (≥3 months in the event of heightened epidemiologic risk) after the last COVID-19 vaccine dose or infection.^8,11

Refrigerator (2^oC to 8^oC):

6 hours (in-use vial or pre-drawn syringe).^8,10

Room temperature (≤25^oC): 6 hours (in-use vial or pre-drawn syringe).^8,10

Effectiveness estimates unknown for current variants.²⁰ Also see footnote i.

Covifenz (Medicago)/

Recombinant spike protein in plant-based virus-like particles, adjuvanted

mRNA vaccine preferred.²⁰

Primary vaccination for 18 to 64 years of age: two 0.5 mL IM doses 21 days apart (8-week interval preferred).^20,26

Immunocompromised^f: As above, plus 3rd dose, with 4 to 8 weeks between each of the three doses (mRNA vaccine preferred).²⁰

N/A

Refrigerator (2^oC to 8^oC). Until expiration date on vaccine and adjuvant vials (unpunctured).²⁶

In-use vial (mixed): 20^oC to 30^oC for 6 hours (do not refrigerate once mixed).²⁶

Effectiveness estimates unknown for current variants.²⁰ Also see footnote i.
Requires mixing of adjuvant and antigen before use (see product labeling for instructions).²⁶
Produced using the genomic sequence of the spike protein of the original strain.²⁶
May contain trace amounts of kanamycin or carbenicillin.²⁶

The adult formulation of the Pfizer-BioNTech vaccine CANNOT be used for children <12 years of age by using a dose-adjusted volume. This is because the resulting volume is too small for an intramuscular injection.²⁹
Canada: For Moderna, 100 mcg (0.5 mL) instead of 50 mcg can be used as the booster in high-risk adults.²⁰
Comirnaty and the Pfizer-BioNTech COVID-19 vaccine authorized (EUA) for ages ≥12 years of age (purple and gray cap vials) can be used interchangeably when prepared according to their respective instructions for use.²⁵
See product labeling for storage in ultra-low freezer, freezer, and thawing before use, if applicable.
Tips to minimize vaccine waste include:^10,23
- Maintain the cold chain to prevent waste due to inappropriate storage conditions.
- Maximize doses drawn from multidose vials using:
  - low dead-volume syringes/needles.
  - techniques to minimize leakage (e.g., multiple puncture locations in the rubber stopper, instead of the same location over and over [this can create a larger hole]).
- Draw up an appropriate number of syringes based on expected vaccination appointments for the day.
- Use syringes in order of expiration time, starting with the earliest expiration date.
- Maintain a waiting list to contact people at the end of the day if there are extra doses available.
US: Immunocompromise = solid organ transplant patients or similar level of immunocompromise. For a full list of CDC-recommended conditions, see https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html#immunocompromised.
Canada: See a full list of immunocompromising conditions, see the Canadian Immunization Guide: https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-3-vaccination-specific-populations/page-8-immunization-immunocompromised-persons.html. Ontario Ministry of Health recommendations for the third dose are available at https://www.health.gov.on.ca/en/pro/programs/publichealth/coronavirus/docs/vaccine/COVID-19_vaccine_third_dose_recommendations.pdf.
Spikevax and the authorized (EUA) RED cap Moderna COVID-19 vaccine with a label with a light blue border can be used interchangeably to provide primary series doses or booster doses.²
Bivalent booster (age-appropriate) preferred, regardless of the number of booster doses previously received, and can be offered to all individuals ≥12 years of age, especially those at increased risk.¹¹
Efficacy: Absolute efficacy of the bivalent booster against hospitalization vs receiving no previous COVID-19 vaccine doses was 84% (95% CI 64% to 93%) in one US cohort.⁴ Absolute efficacy of the bivalent booster against infection vs receiving no previous COVID-19 vaccine doses varied based on age and number of previous monovalent doses and ranged from 19% to 50%.⁵ The bivalent booster was also more effective than previous vaccination with the monovalent booster in regard to preventing infection and hospitalization.^4,5 Note that many of the patients with no previous doses probably had at least some natural immunity. For the most current CDC-authored vaccine effectiveness studies, see COVID-19 Vaccine Effectiveness Monthly Update at https://covid.cdc.gov/covid-data-tracker/#vaccine-effectiveness.

Abbreviations: EUA = Emergency Use Authorization; IM = intramuscular; NS = normal saline; UK = United Kingdom.

The CDC has interim recommendations for COVID-19 vaccine administration errors and deviations available at https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us-appendix.html#appendix-d.

Fact Sheets and Product Labeling

Comirnaty (PURPLE cap) prescribing information (US): https://www.fda.gov/vaccines-blood-biologics/comirnaty
Comirnaty (GRAY cap) prescribing information (US): https://www.fda.gov/vaccines-blood-biologics/comirnaty
Pfizer-BioNTech vaccine EUA fact sheet (12 years of age and older) for healthcare professionals (US): https://www.fda.gov/media/153713/download
Pfizer-BioNTech vaccine EUA fact sheet (12 years of age and older [including bivalent booster]) for patients (US): https://www.fda.gov/media/153716/download
Pfizer-BioNTech vaccine EUA fact sheet (12 years of age and older-Do Not Dilute) for healthcare professionals (US): https://www.fda.gov/media/153715/download
Pfizer-BioNTech vaccine EUA fact sheet (5 through 11 years of age) for healthcare professionals (US): https://www.fda.gov/media/153714/download
Pfizer-BioNTech vaccine EUA fact sheet (5 through 11 years of age [including bivalent booster]) for patients (US): https://www.fda.gov/media/153717/download
Pfizer-BioNTech vaccine EUA fact sheet (6 months through 4 years of age [including bivalent booster]) for healthcare professionals (US): https://www.fda.gov/media/159312/download
Pfizer-BioNTech vaccine EUA fact sheet (6 months through 4 years of age) for patients (US): https://www.fda.gov/media/159313/download
Pfizer-BioNTech vaccine EUA fact sheet (booster dose for 12 years of age and older) for healthcare professionals (US): https://www.fda.gov/media/161327/download
Pfizer-BioNTech vaccine EUA fact sheet (booster dose for 5 through 11 years of age) for healthcare professionals (US): https://www.fda.gov/media/162250/download
Spikevax prescribing information (US): https://www.fda.gov/vaccines-blood-biologics/spikevax
Moderna vaccine EUA fact sheet for healthcare professionals (US) (Primary series, ≥12 years of age): https://www.fda.gov/media/157233/download
Moderna vaccine EUA fact sheet for healthcare professionals (US) (Bivalent booster, 6 years of age and older): https://www.fda.gov/media/161318/download
Moderna vaccine EUA fact sheet for patients (US) (12 years of age and older [including bivalent booster]): https://www.fda.gov/media/144638/download
Moderna vaccine EUA fact sheet for healthcare professionals (US) (Primary series, 6 through 11 years of age): https://www.fda.gov/media/159308/download
Moderna vaccine EUA fact sheet for patients (US) (6 years of age and older [primary series and bivalent booster]): https://www.fda.gov/media/159310/download
Moderna vaccine EUA fact sheet for healthcare professionals (US) (Primary series presentation, 6 months through 5 years of age): https://www.fda.gov/media/159307/download
Moderna vaccine EUA fact sheet for patients (US) (6 months through 5 years of age [primary series and bivalent booster]): https://www.fda.gov/media/159309/download
Moderna vaccine EUA fact sheet for healthcare professionals (US) (Bivalent booster, 6 months through 5 years of age): https://www.fda.gov/media/163785/download
Moderna vaccine EUA fact sheet for patients (US) (Bivalent booster, 6 months through 5 years of age): https://www.fda.gov/media/159309/download
Janssen (J&J) vaccine EUA fact sheet for healthcare professionals (US): https://www.fda.gov/media/146304/download
Janssen (J&J) vaccine fact sheet for patients (US): https://www.fda.gov/media/146305/download
Novavax vaccine EUA fact sheet for healthcare professionals (US): https://www.fda.gov/media/159897/download
Novavax vaccine fact sheet for patients (US): https://www.fda.gov/media/159898/download
Current Canadian product monographs for Covid-19 vaccines available in Canada can be found at Health Canada’s Drug Product Database (https://health-products.canada.ca/dpd-bdpp/index-eng.jsp).

References

Product monograph for Spikevax Bivalent. Moderna Therapeutics. Cambridge, MA 02139. September 2022.
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Moderna COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Primary series for 12 years and older. December 8, 2022. https://www.fda.gov/media/157233/download. (Accessed December 16, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) for the Moderna COVID-19 vaccine, bivalent (original and omicron BA.4/BA.5). December 8, 2022. https://www.fda.gov/media/161318/download. (Accessed December 16, 2022).
Surie D, DeCuir J, Zhu Y, et al. Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19–Associated Hospitalization Among Immunocompetent Adults Aged ≥65 Years — IVY Network, 18 States, September 8–November 30, 2022. MMWR Morb Mortal Wkly Rep. 2022 Dec 30;71(5152):1625-1630.
Link-Gelles R, Ciesla AA, Fleming-Dutra KE, et al. Effectiveness of Bivalent mRNA Vaccines in Preventing Symptomatic SARS-CoV-2 Infection — Increasing Community Access to Testing Program, United States, September–November 2022. MMWR Morb Mortal Wkly Rep. 2022 Dec 2;71(48):1526-1530.
CDC. Vaccine storage and handling kit. Updated April 12, 2022. https://www.cdc.gov/vaccines/hcp/admin/storage/toolkit/storage-handling-toolkit.pdf. (Accessed August 30, 2022).
Accorsi EK, Britton A, Shang N, et al. Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron. N Engl J Med. 2022 Jun 23;386(25):2433-2435.
Product monograph for Nuvaxovid. Novavax. Gaithersburg, MD 20878. December 2022.
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Janssen COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). May 5, 2022. https://www.fda.gov/media/146304/download. (Accessed August 30, 2022).
USP. COVID-19 vaccine handling toolkit: operational considerations for healthcare practitioners. Version 6.0. October 2022. https://www.usp.org/covid-19/vaccine-handling-toolkit. (Accessed November 17, 2022).
National Advisory Committee on Immunization (NACI). An Advisory Committee Statement (ACS). Recommendations on the use of bivalent Omicron-containing mRNA COVID-19 vaccines. September 1, 2022. https://www.canada.ca/content/dam/phac-aspc/documents/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-bivalent-Omicron-containing-mrna-covid-19-vaccines.pdf. (Accessed September 1, 2022).
Moderna. Spikevax dosage and administration. July 2022. https://assets.ctfassets.net/qxn1nenx7ve8/4n0cJMbQSI8z2hNJCVA43u/6fcf0f6a71cc0989c89630767743b63f/SPX-Dosing_Administrations-Storage-Handling_DASH_-CA-English.pdf. (Accessed November 17, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Pfizer-Biontech Covid-19 vaccine to prevent coronavirus disease 2019 (COVID-19) for 12 years of age and older-do not dilute. December 8, 2022. https://www.fda.gov/media/153715/download. (Accessed December 17, 2022).
FDA, Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Novavax COVID-19 vaccine, adjuvanted to prevent coronavirus disease 2019 (COVID-19). October 19, 2022. https://www.fda.gov/media/159897/download. (Accessed November 9, 2022).
Blumenthal KG, Freeman EE, Saff RR, et al. Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2. N Engl J Med 2021;384:1273-1277.
Product monograph for Vaxzevria. AstraZeneca Canada. Mississauga, ON L4Y 1M4. December 2022.
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Pfizer-Biontech COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Primary series for 12 years of age and older. Dilute before use. December 22, 2022. https://www.fda.gov/media/153713/download. (Accessed December 17, 2022).
Product monograph for Comirnaty. Pfizer. Canada. Kirkland, QC H9J 2M5. September 2022.
Product information for Comirnaty(purple cap). Pfizer. New York, NY 10017. July 2022.
Government of Canada. COVID-19 vaccine: Canadian Immunization Guide. Date modified: December 22, 2022. https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-26-covid-19-vaccine.html#t4. (Accessed December 17, 2022).
Product information for Spikevax. Moderna US. Cambridge, MA 02139. January 2022.
Product monograph for Spikevax. Moderna Therapeutics. Cambridge, MA 02139. July 2022.
Coppock K. ISMP provides recommendations for avoiding COVID-19 vaccination administration errors. January 15, 2021. https://www.pharmacytimes.com/view/ismp-provides-recommendations-for-avoiding-covid-19-vaccination-administration-errors. (Accessed September 1, 2022).
Product monograph for Janssen COVID-19 vaccine. Janssen. Toronto, ON M3C 1L9. December 2022.
CDC. Use of COVID-19 vaccines in the United States. Interim clinical considerations. Last updated November 14, 2022. https://www.cdc.gov/vaccines/covid-19/clinical-considerations/covid-19-vaccines-us.html. (Accessed August 29, 2022).
Product monograph for Covifenz. Medicago. Quebec, CA G1V 3V9. February 2022.
Product information for Comirnaty (gray cap). Pfizer. New York, NY 10017. August 2022.
NCCN: Cancer and COVID-19 Vaccination. Recommendations of the National Comprehensive Cancer Network (NCCN) Advisory Committee on COVID-19 vaccination and pre-exposure prophylaxis. Version 7.0. September 22, 2022. https://www.nccn.org/docs/default-source/covid-19/2021_covid-19_vaccination_guidance_v5-0.pdf?sfvrsn=b483da2b_110. (Accessed August 29, 2022).
American Pharmacists Association. Considerations for COVID-19 vaccination in adolescents and children. July 7, 2022. https://www.pharmacist.com/Practice/COVID-19/Know-the-Facts/Considerations-for-COVID-19-vaccination-in-adolescents-and-children. (Accessed August 29, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Pfizer-Biontech COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Primary series for 5 through 11 years of age. Dilute before use. December 8, 2022. https://www.fda.gov/media/153714/download. (Accessed December 17, 2022).
FDA. Amended Emergency Use Authorization-Concurrence. Janssen COVID-19 vaccine. April 7, 2022. https://www.fda.gov/media/157554/download. (Accessed September 1, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Pfizer-BionNTech COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19) for 6 months through 4 years of age. Dilute before use. December 8, 2022. https://www.fda.gov/media/159312/download. (Accessed December 16, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Moderna COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Primary series presentation. 6 months through 5 years of age. December 8, 2022. https://www.fda.gov/media/159307/download. (Accessed December 16, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA) of the Moderna COVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19). Primary series. 6 years through 11 years of age. December 8, 2022. https://www.fda.gov/media/159308/download. (December 16, 2022).
Government of Canada. NACI statement. Recommendations on the use of Moderna Spikevax COVID-19 vaccine in children 6 months to 5 years of age. July 14, 2022. https://www.canada.ca/content/dam/phac-aspc/documents/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-moderna-spikevax-covid-19-vaccine-children-6-months-5-years.pdf. (Accessed August 31, 2022).
Price AM, Olson SM, Newhams MM, et al. BNT162b2 Protection against the Omicron Variant in Children and Adolescents. N Engl J Med. 2022 May 19;386(20):1899-1909.
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA). Pfizer-Biontech COVID-19 vaccine, bivalent (original and Omicron BA.4/BA.5). Booster dose for 5 through 11 years of age. Dilute before use. December 8, 2022. https://www.fda.gov/media/162250/download. (Accessed December 17, 2022).
FDA. Fact sheet for healthcare providers administering vaccine (vaccination providers). Emergency use authorization (EUA). Pfizer-Biontech COVID-19 vaccine, bivalent (original and Omicron BA.4/BA.5). Booster dose for 12 years of age and older. Do not dilute. December 8, 2022. https://www.fda.gov/media/161327/download. (Accessed December 17, 2022).
Product monograph for Comirnaty Original/Omicron BA.1. Pfizer Canada. Kirkland, QC H9J 2M5. October 2022.
Product monograph for Comirnaty Original/Omicron BA.4/BA.5. Pfizer Canada. Kirkland, QC H9J 2M5. December 2022.
FDA. Fact sheet for healthcare providers administering vaccine (vaccine providers). Emergency use authorization (EUA). Moderna COVID-19 vaccine bivalent (original and Omicron BA.4/BA.5) Booster dose for 6 months through 5 years of age. December 8, 2022. https://www.fda.gov/media/163785/download. (Accessed December 16, 2022).
Product monograph for Spikevax Bivalent. Original/Omicron BA.4/BA.5. Ingmar Strategies. Oakville, ON L6L 0C4. September 2022.

Cite this document as follows: Clinical Resource,COVID-19 Vaccines. Pharmacist’s Letter/Prescriber’s Letter. January 2023. [390126]

COVID-19 Vaccines

Related Articles